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Department of Environmental Medicine and Molecular Toxicology,
Tohoku University Graduate School of Medicine

研究業績research performance


発表年別:2021年2020年2019年2018年2017年2016年2015年2014年2013年2012年2011年2010年2009年2008年2007年2006年2005-2001年2000-1996年1995年以前

2021年

原著論文

  1. Marutani E, Morita M, Hirai S, Kai S, Grange RMH, Miyazaki Y, Nagashima F, Trager L, Magliocca A, Ida T, Matsunaga T, Flicker DR, Corman BHP, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin DN, Ihara H, Olenchock BA, Shen X, Nishida M, Hanaoka K, Kevil CG, Xian M, Bloch DB, Akaike T, Hindle AG, Motohashi H, Ichinose F.
    The pivotal role of sulfide catabolism in hypoxia tolerance.
    Nature Commun. 12:3108 (2021)
  2. Kasamatsu S, Ida T, Koga T, Asada K, Motohashi H, Ihara H, Akaike T.
    High-precision sulfur metabolomics innovated by a new specific probe for trapping reactive sulfur species.
    Antioxid Redox Signal. 34:1407-1419 (2021)
  3. Zhang T, Tsutsuki H, Islam W, Ono K, Takeda K, Akaike T, Sawa T.
    High-precision sulfur metabolomics innovated by a new specific probe for trapping reactive sulfur species.
    Antioxid Redox Signal. 34:101930 (2021)
  4. Dóka É, Arnér ESJ, Schmidt EE, Dick TP, van der Vliet A, Yang J, Wallace JL, Cirino G, Olson K, Motohashi H, Fukuto JM, Pluth M, Feelisch M, Akaike T, Wink DA, Ignarro LJ, Nagy P.
    Comment on “Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity”.
    Sci Adv. 7:eabe7006 (2021)
  5. Ono K, Kitamura Y, Zhang T, Tsutsuki H, Rahman A, Ihara T, Akaike T, Sawa T.
    Cysteine hydropersulfide inactivates β-lactam antibiotics with formation of ring-opened carbothioic S-acids in bacteria.
    ACS Chem Biol. 16:731-739 (2021)
  6. Zhang T, Tsutsuki H, Ono K, Akaike T, Sawa T.
    Antioxidative and anti-inflammatory actions of reactive cysteine persulfides.
    J Clin Biochem Nutr. 68:5-8 (2021)
  7. Sugawara K, Toyoda H, Kimura M, Hayasaka S, Saito H, Kobayashi H, Ihara K, Ida T, Akaike T, Ando E, Hyodo M, Hayakawa Y, Hamamoto S, Uozumi N.
    Loss of cell wall integrity genes cpxA and mrcB causes flocculation in Escherichia coli.
    Biochem J. 478:41-59 (2021)


2020年

原著論文

  1. Nagy P, Doka E, Ida T, Akaike T.
    Measuring reactive sulfur species and thiol oxidation states: Challenges and cautions in relation to alkylation based protocols.
    Antioxid Redox Signal. 33:1174-1189 (2020)
  2. Sawa T, Motohashi H, Ihara H, Akaike T.
    Enzymatic regulation and biological functions of reactive cysteine persulfides and polysulfides.
    Biomolecules. 10:1245 (2020)
  3. Tawarayama H, Suzuki N, Inoue-Yanagimachi M, Himori N, Tsuda S, Sato K, Ida T, Akaike T, Kunikata H, Nakazawa T.
    Glutathione trisulfide prevents lipopolysaccharide-induced inflammatory gene expression in retinal pigment epithelial cells.
    Ocul Immunol Inflamm. 20:1-12 (2020)
  4. Tsutsuki H, Kasamatsu S, Kunieda K, Ida T, Sawa T, Sasakawa N, Akaike T, Ihara H.
    8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells..
    Biochem Biophys Res Commun. 526:225-230 (2020)
  5. Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M.
    Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling.
    Cardiovasc Res. 116:51-62 (2020)
  6. É. Dóka, T. Ida, M. Dagnell, Y. Abiko, N. L. Cong, N. Balog, T. Takata, B. Espinosa, A. Nishimura, Q. Cheng, Y. Funato, H. Miki, J. Fukuto, J. R. Prigge, E. E. Schmidt, E. S. J. Arnér, Y. Kumagai, T. Akaike, P. Nagy.
    Control of protein function through oxidation and reduction of persulfidated states.
    Sci Adv. 6:eaax8358 (2020)

2019年

原著論文

  1. Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.
    AUTACs: Cargo-Specific Degraders Using Selective Autophagy.
    Moll Cell. pii: S1097-2765(19)30694-X (2019)
  2. Chen W, Matsunaga T, Neill DL, Yang CT, Akaike T, Xian M.
    Rational Design of a Dual-Reactivity-Based Fluorescent Probe for Visualizing Intracellular HSNO.
    Angew Chem Int Ed Engl. [Epub ahead of print] (2019)
  3. Nishimura A, Nasuno R, Yoshikawa Y, Jung M, Ida T, Matsunaga T, Morita M, Takagi H, Motohashi H, Akaike T.
    Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells.
    J Biol Chem. 294:13781-13788 (2019)
  4. Yang CT, Wang Y, Marutani E, Ida T, Ni X, Xu S, Chen W, Zhang H, Akaike T, Ichinose F, Xian M.
    Data-Driven Identification of Hydrogen Sulfide Scavengers.
    Angew Chem Int Ed Engl. 58:10898-10902 (2019)
  5. Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.
    Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.
    Proc Natl Acad Sci U S A. 116:13016-13025 (2019)
  6. Nishimura A, Shimoda K, Tanaka T, Toyama T, Nishiyama K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y, Nishida M.
    Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.
    Sci Signal. pii: eaaw1920 (2019)
  7. Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y.
    Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both.
    Environ Health Perspect. 127:67002 (2019)
  8. Kyogoku Y, Sugiura H, Ichikawa T, Numakura T, Koarai A, Yamada M, Fujino N, Tojo Y, Onodera K, Tanaka R, Sato K, Sano H, Yamanaka S, Itakura K, Mitsune A, Tamada T, Akaike T, Ichinose M.
    Nitrosative stress in patients with asthma-chronic obstructive pulmonary disease overlap.
    J Allergy Clin Immunol. 144:972-983 (2019)
  9. Ikeda M, Ishima Y, Chuang VTG, Sakai M, Osafune H, Ando H, Shimizu T, Okuhira K, Watanabe H, Maruyama T, Otagiri M, Akaike T, Ishida T.
    Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities.
    Molecules. pii: E1689 (2019)
  10. Zhang T, Ono K, Tsutsuki H, Ihara H, Islam W, Akaike T, Sawa T.
    Enhanced cellular polysulfides negatively regulate TLR4 signaling and mitigate lethal endotoxin shock.
    Cell Chem Biol. pii: S2451-9456(19)30037-6 (2019)
  11. Takata T, Tsukuda A, Tsuchiya Y, Akaike T, Watanabe Y.
    The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation.
    Nitric Oxide. 86: 68-75 (2019)
  12. Kishimoto Y, Kasamatsu S, Yanai S, Endo S, Akaike T, Ihara H.
    8-Nitro-cGMP attenuates context-dependent fear memory in mice.
    Biochem Biophys Res Commun. 511: 141-147 (2019)
  13. Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.
    The uptake and release of polysulfur cysteine species by cells: physiological and toxicological implications.
    Chem Res Toxicol. 32: 447-455 (2019)
  14. Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.
    Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.
    Redox Biol. 21: 101096 (2019)
  15. Nagayama K, Miyamoto Y, Kaneko K, Yoshimura K, Sasa K, Akaike T, Fujii S, Izumida E, Uyama R, Chikazu D, Maki K, Kamijo R.
    Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E2.
    In Vitro Cell Dev Biol Anim. 55: 45-51 (2019)
  16. Kishimoto Y, Akaike T, Ihara H.
    SNAP-25 S-Guanylation and SNARE complex formation.
    Methods Mol Biol. 1860: 163-173 (2019)
  17. Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P.
    Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell?
    Br J Pharmacol. 176: 646-670 (2019)
  18. Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM.
    The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems.
    Br J Pharmacol. 176: 671-683 (2019)
  19. Fujii S, Sawa T, Motohashi H, Akaike T.
    Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells.
    Br J Pharmacol. 176: 607-615 (2019)



総説

  1. 西村明、本橋ほづみ、赤池孝章
    エレクトロンバイオダイナミクスが支える生命の生存戦略【活性イオウによる生体防御とエネルギー代謝】
    月刊細胞(細胞) Vol.51, 380-383 (2019)
  2. 西村明、本橋ほづみ、赤池孝章
    活性イオウによる生体防御とエネルギー代謝 (特集 エレクトロンバイオダイナミクスが支える生命の生存戦略)
    月刊細胞(細胞) Vol.51, 380-383 (2019)
  3. 居原秀、本橋ほづみ、赤池孝章
    活性硫黄研究の新展開
    生化学 Vol.91, 388-398 (2019)
  4. 赤池孝章
    生物のエネルギー代謝 : イオウ呼吸の再発見
    学士会会報 57-62 (2019)
                                    ▲年度別メニューへ戻る

2018年

原著論文

  1. Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.
    Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol- based redox signaling?
    Redox Biol. 14: 379-385 (2018)
  2. Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.
    8-Nitro-cGMP attenuates the interaction between SNARE complex and complexin through S-guanylation of SNAP-25.
    ACS Chem Neurosci. 9:217-223 (2018)
  3. Saito H, Godo S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T, Shimokawa H.
    Important role of endothelial caveolin-1 in the protective role of EDH against NO-mediated nitrative stress in microcirculation in mice.
    J Cardiovasc Pharmacol.71:113-126 (2018).
  4. Khan S, Fujii S, Matsunaga T, Nishimura A, Ono K, Ida T, Ahmed KA, Okamoto T, Tsutsuki H, Sawa T, Akaike T.
    Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling.
    Cell Chem Biol. 25:1403-1413.e4 (2018)
  5. Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H.
    Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons.
    Biochem Biophys Res Commun. 495:2165-2170 (2018)
  6. Kaneko K, Miyamoto Y, Tsukuura R, Sasa K, Akaike T, Fujii S, Yoshimura K, Nagayama K, Hoshino M, Inoue S, Maki K, Baba K, Chikazu D, Kamijo R.
    8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL.
    Nitric Oxide 72:46-51 (2018)
  7. Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
    Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
    Sci Signal. 11: pii: eaat5185 (2018)
  8. Sawa T, Ono K, Tsutsuki H, Zhang T, Ida T, Nishida M, Akaike T.
    Reactive cysteine persulphides: Occurrence, biosynthesis, antioxidant activity, methodologies, and bacterial persulphide signalling.
    Adv Microb Physiol. 72: 1-28 (2018)
  9. Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.
    Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.
    FEBS Lett. 592: 2140-2152 (2018)



総説

  1. 本橋ほづみ、赤池孝章、内田浩二、末松 誠
    レドックス疾患学:レドックス制御の破綻による病態と新たな疾患概念
    実験医学増刊 Vol.36 No.5, 10-16 (2018)
  2. 澤 智裕、赤池孝章
    活性イオウによる生体防御応答、エネルギー代謝と寿命制御
    実験医学増刊 Vol.36 No.5, 17-23 (2018)
  3. 西村 明、赤池孝章
    哺乳類におけるイオウ呼吸の発見
    医学のあゆみ Vol.267 No.7, 532-533 (2018)
  4. 西村 明、井田智章、赤池孝章
    SH(ポリスルフィド)の酸化
    生体の科学 Vol.69 No.5, 446-447 (2018)
  5. 西村 明、井田智章、赤池孝章
    ポリスルフィド化
    生体の科学 Vol.69 No.5, 448-449 (2018)
  6. 西村 明、赤池孝章
    活性イオウ分子:システインパースルフィドの新規生合成経路の発見とその生理機能
    化学と生物 Vol.56 No.8, 518-519 (2018)
  7. 井田智章、西村 明、守田匡伸
    活性イオウメタボローム: イオウ代謝物とレドックスバイオマーカー
    実験医学増刊 Vol.36 No.5, 233-241 (2018)
  8. 西村 明、赤池孝章
    イオウ呼吸の発見 ペルスルフィド産生酵素による新しいエネルギー代謝
    現代化学 No.565, 55-59 (2018)
                                    ▲年度別メニューへ戻る

2017年

原著論文

  1. Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam Md. M, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.
    Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
    Nat. Commun. 8: 1177 (2017)
  2. Tomida J, Morita Y, Shibayama K, Kikuchi K, Sawa T, Akaike T, Kawamura Y.
    Diversity and microevolution of CRISPR loci in Helicobacter cinaedi.
    PLoS One. 12: e0186241 (2017)
  3. Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, Ishizaki K, Toyama T, Yoshida E, Abdul Hamid H, Jung M, Matsunaga T, Fujii S, Sawa T, Nishida M, Kumagai Y, Akaike T.
    Exposure to electrophiles impairs reactive persulfide-dependent redox signaling in neuronal cells.
    Chem Res Toxicol. 30: 1673-1684 (2017)
  4. Takamiya R, Uchida K, Shibata T, Maeno T, Kato M, Yamaguchi Y, Ariki S, Hasegawa Y, Saito A, Miwa S, Takahashi H, Akaike T, Kuroki Y, Takahashi M.
    Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke.
    Sci Rep. 7: 8304 (2017)
  5. Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M.
    Production of reactive persulfide species in chronic obstructive pulmonary disease.
    Thorax., pii: thoraxjnl-2016-209359 (2017)
  6. Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.
    Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue.
    Biochem J. 474: 2547-2562 (2017)
  7. Hoshino M, Kaneko K, Miyamoto Y, Yoshimura K, Suzuki D, Akaike T, Sawa T, Ida T, Fujii S, Ihara H, Tanaka J, Tsukuura R, Chikazu D, Mishima K, Baba K, Kamijo R.
    8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage.
    Free Radic Biol Med. 110: 63-71 (2017)
  8. Ikeda M, Ishima Y, Shibata A, Chuang VTG, Sawa T, Ihara H, Watanabe H, Xian M, Ouchi Y, Shimizu T, Ando H, Ukawa M, Ishida T, Akaike T, Otagiri M, Maruyama T.
    Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.
    Anal Chim Acta. 969: 18-25 (2017)
  9. Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
    Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.
    Nucleic Acids Res. 45: 435-445 (2017)
  10. Ahmed KM, Zhang T, Ono K, Tsutsuki H, Ida T, Akashi S, Miyata K, Oike Y, Akaike T, Sawa T.
    Synthesis and Characterization of 8-Nitroguanosine 3′,5′-Cyclic Monophosphorothioate Rp-isomer as a Potent Inhibitor of Protein Kinase G1α.
    Biol. Pharm. Bull. 40: 365-374 (2017)
  11. Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
    1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides.
    Free Radic Biol Med. 104: 118-128 (2017)
  12. Ono K, Jung M, Zhang T, Tsutsuki H, Sezaki H, Ihara H, Wei FY, Tomizawa K, Akaike T, Sawa T.
    Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome.
    Free Radic Biol Med. 106: 69-79(2017)
  13. Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.
    Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors.
    Sci Rep.7: 41984 (2017)
  14. Ihara H, Kitamura A, Kasamatsu S, Ida T, Yuki K, Tsutsuki H, Sawa T, Watanabe Y, Akaike T.
    Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation.
    Biochem J. pii: BCJ20160999 (2017)




 総説

  1. Sawa T, Kumagai Y, Akaike T.
    Regulation of redox signaling by a nitrated nucleotide and reactive cysteine persulfides.
    In: Nitric Oxide: Biology and Pathobiology. 3rd ed. (Ignarro LJ, Freeman BA, eds.; Academic Press, London). 231-235 (2017)
  2. Álvarez L, Bianco CL, Toscano JP, Lin J, Akaike T, Fukuto JM.
    Chemical biology of hydropersulfides and related species: Possible roles in cellular protection and redox signaling.
    Antioxid Redox Signal. 27: 622-633 (2017)
  3. Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
    Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.
    Free Radic Biol Med. pii: S0891-5849(17)30033-3. (2017)
  4. 藤井重元、赤池孝章
    ニトロ化環状ヌクレオチドと活性イオウ分子によるレドックスシグナル制御と生理機能
    化学療法の領域 33: 2194-2200 (2017)
  5. 笠松真吾、守田匡伸、赤池孝章
    レドックスシグナルの活性イオウ分子制御
    ファルマシア Vol.53 No.3 210-214 (2017)
  6. 西村 明、赤池孝章
    活性イオウ分子:システインパースルフィドの新規生合成経路の発見とその生理機能
    硫酸と工業 Vol.70 No.11, 1-9 (2017)



▲年度別メニューへ戻る

2016年

原著論文

  1. Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T.
    Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1.
    Biochem Biophys Res Commun. 480: 180-186 (2016)
  2. Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.
    Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION.
    J Biol Chem. 291: 22714-22720 (2016)
  3. Tsutsuki H, Jung M, Zhang T, Ono K, Ida T, Kunieda K, Ihara H, Akaike T, Sawa T.
    Endogenous occurrence of protein S-guanylation in Escherichia coli: Target identification and genetic regulation.
    Biochem Biophys Res Commun. 478: 7-11 (2016)
  4. Yugami M, Odagiri H, Endo M, Tsutsuki H, Fujii S, Kadomatsu T, Masuda T, Miyata K, Terada K, Tanoue H, Ito H, Morinaga J, Horiguchi H, Sugizaki T, Akaike T, Gotoh T, Takai T, Sawa T, Mizuta H, Oike Y.
    Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.
    J Biol Chem. 91: 18843-52 (2016)
  5. Kawamura Y, Tomida J, Miyoshi-Akiyama T, Okamoto T, Narita M, Hashimoto K, Cnockaert M, Vandamme P, Morita Y, Sawa T, Akaike T.
    Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines.
    Syst Appl Microbiol. 39: 307-12 (2016)
  6. Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.
    Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation.
    Biochemistry. 55: 751-61 (2016)




総説

  1. Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    Redox signaling regulated by electrophiles and reactive sulfur species.
    J Clin Biochem Nutr. 5: 91-8(2016)
  2. Kasamatsu, S., Nishimura, A., Morita, M., Matsunaga, T., Ab dul Hamid, H., Akaike, T.
    Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation.
    Molecules 21: 1721(2016)
  3. Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
    The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.
    Free Radic Biol Med. 97: 136-47 (2016)
  4. Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.
    Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.
    Arch Biochem Biophys. 595: 140-6 (2016)
  5. 笠松真吾、藤井重元、赤池孝章
    酸化ストレスシグナルと8-ニトロ-cGMPによる感染防御機構
    医学のあゆみ「マクロファージのすべて」Vol.259, No.5 397-401 (2016)
  6. 井田智章、松永哲郎、藤井重元、澤智裕、赤池孝章
    活性イオウ含有分子の再発見とその生物活性
    薬理学会誌 Vol. 147 No. 5 p. 278-284(2016)
  7. 笠松真吾、藤井重元、赤池孝章
    活性イオウ分子種によるタンパク質チオール修飾:ポリスルフィド化タンパク質解析の最先端技法
    薬理学会誌 Vol. 147 No. 5 p. 299-302(2016)



▲年度別メニューへ戻る

2015年

原著論文

  1. Chen W, Rosser EW, Matsunaga T, Pacheco A, Akaike T, Xian M.
    The Development of Fluorescent Probes for Visualizing Intracellular Hydrogen Polysulfides.
    Angew Chem Int Ed Engl. 54: 13961-13965 (2015)
  2. Kunieda K, Tsutsuki H, Ida T, Kishimoto Y, Kasamatsu S, Sawa T, Goshima N, Itakura M, Takahashi M, Akaike T, Ihara H.
    8-Nitro-cGMP enhances SNARE complex formation through S-guanylation of Cys90 in SNAP25.
    ACS Chem Neurosci. 6: 1715–1725 (2015)
  3. Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M.
    Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.
    J Mol Med (Berl). 93: 879-889 (2015).
  4. Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    Involvement of Reactive Persulfides in Biological Bismethylmercury Sulfide Formation.
    Chem Res Toxicol. 28: 1301-1306(2015).
  5. Honda K, Yamada N, Yoshida R, Ihara H, Sawa T, Akaike T, Iwai S.
    8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis.
    Plant Cell Physiol. 56: 1481-61489(2015).
  6. Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
    Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1.
    Mol Ther. 23: 549-60 (2015).
  7. Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.
    Chem Res Toxicol. 28: 838-47 (2015).
  8. Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F.
    Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia.
    J Am Heart Assoc. 4: pii: e002125. (2015).

 総説
  1. Saund SS, Sosa V, Henriquez S, Nguyen QN, Bianco CL, Soeda S, Millikin R, White C, Le H, Ono K, Tantillo DJ, Kumagai Y, Akaike T, Lin J, Fukuto JM.
    The chemical biology of hydropersulfides (RSSH): Chemical stability, reactivity and redox roles.
    Arch Biochem Biophys. 588: 15-24 (2015).
  2. Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y.
    Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides.
    Chem Res Toxicol. 28: 1796-862 (2015).
  3. 赤池孝章
    細菌感染における酸化ストレスシグナル制御と感染防御論
    日本細菌学雑誌 Vol. 70 No. 3 p. 339-349 (2015)
  4. 松永哲郎、藤井重元、赤池孝章
    9. 感染性微生物:H. cinaedi.
    動脈硬化予防 14, 66-71 (2015)
  5. 笠松真吾、井田智章、藤井重元、赤池孝章
    活性イオウ分子による酸化・ニトロ化ストレス制御
    Respiratory Medical Research 3, 70-75 (2015)
  6. 赤池孝章、藤井重元
    活性システインパースルフィド
    別冊・医学のあゆみ「レドックス UPDATE ー ストレス制御の臨床医学・健康科学」(淀井淳司、平家俊男 監修/生田孝一、杉田昌彦、塚原孝一、豊國伸哉、前田裕弘 編)
    医歯薬出版社(東京都)、p.41-44 (2015)
  7. 赤池孝章、藤井重元
    Nitric oxide (NO)
    生体の科学 66, 396-397 (2015)
  8. 河村好章、富田純子、岡本竜哉、澤 智裕、赤池孝章
    H.cinaedi と敗血症
    臨床と微生物 Vol.42, 177-182 (2015)
  9. 赤池孝章
    H2Sの生体内生成とシグナル機能の正体:システインパースルフィドの再発見と新機能
    細胞工学 Vol.34, 346-348 (2015)
  10. 井田智章、藤井重元、赤池孝章
    RSSによる抗酸化・レドックスシグナル制御
    細胞工学 Vol.34,354-357 (2015)
  11. 赤池孝章、藤井重元
    活性イオウ分子種による酸化ストレス制御
    臨床免疫・アレルギー科 63, 502-506 (2015)

▲年度別メニューへ戻る

2014年

原著論文

  1. Rahaman MM, Sawa T, Ahtesham AK, Khan S, Inoue H, Irie A, Fujii S, and Akaike T.
    S-Guanylation proteomics for redox-based mitochondrial signaling.
    Antioxid. Redox Signal. 20: 295-307 (2014).
  2. Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Masuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H and Oike Y.
    Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress.
    Mol. Cancer Res 12: 239-49 (2014)
  3. Kasamats S, Watanabe Y, Sawa T, Akaike T and Ihara H.
    Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons.
    Biochem. J. 459: 251-63(2014)
  4. Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, and *Yamagata K.
    SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway
    Cell Metab. 9: 712-21(2014)
  5. Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, and Akaike T.
    Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling
    Proc. Natl. Acad. Sci. USA 111: 7606-11 (2014)
  6. Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman Md M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, and Akaike T.
    Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.
    Sci. Rep. 4: 4680 (2014)
  7. Okubo H, Goto M, Sato M, Sugiyama T, Kawano M, Matsunaga T, and Akaike T.
    Helicobacter cinaedi meningitis: a case report and review of previous cases.
    J. Neurol. Sci. 347: 396-397 (2014)

総説

  1. Nishida M, Toyama T, and Akaike T.
    Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling.
    J. Mol Cell Cardiol. 73: 10-7 (2014)
  2. Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P, Xian M, Lin J, and Fukuto JM.
    Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility.
    Free Radic. Biol. Med. 77: 82-94 (2014)
  3. 赤池孝章.
    寄り道研究:Serendipityと8-ニトロ-cGMPとの出会い
    化学療法の領域 Vol.30, 122-128 (2014)
  4. 井田智章、赤池孝章、澤 智裕、藤井重元
    活性酸素と炎症
    感染・炎症・免疫 44(2):16-21 (2014)
  5. 赤池孝章
    システインパースルフィドの生体内生成と生理機能再発現:活性イオウ分子による抗酸化・レドックスシグナル制御
    実験医学 Vol.36, 2123-2126 (2014)
  6. 藤井重元、井田智章、澤 智裕、赤池孝章
    第3章炎症の慢性化と収束を制御するメディエーター
    4. フリーラジカル制御系:硫化水素・活性イオウ分子と炎症
    実験医学 Vol.32, 131-137 (2014)
  7. Kawamura Y, Tomida J, Morita Y, Fujii S, Okamoto T, Akaike T.
    Clinical and bacteriological characteristics of Helicobacter cinaedi infection.
    J Infect Chemother. 20: 517-526 (2014)
  8. 赤池孝章.
    活性酸素による多階層シグナル伝達機構とレドックス恒常性制御
    YAKUGAKU ZASSHI 134: 515-519(2014)

▲年度別メニューへ戻る

2013年

原著論文

  1. Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
    S-Nitrosylated a-1-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis.
    FASEB J 27: 391-398 (2013).
  2. Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, and Katsuki H.
    Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity.
    Neuroscience 231: 206-215 (2013).
  3. Joudoi T, Shichiri Y, Kamizono N, Akaike T, Sawa T, Yoshitake J, Yamada N, Iwai S.
    Nitrated cyclic GMP modulates guard cell signaling in Arabidopsis.
    Plant Cell 25: 558-571 (2013).
  4. Saito Y, Ito C, Fujii S, Sawa T, Akaike T, and Arimoto H.
    Fluorescent probes for live cell imaging of endogenous guanine nitration.
    Chembiochem 14: 1068-1071 (2013).
  5. Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, and Yamagata K.
    Inhibition of H3K18 deacetylation of SIRT7 by Myb-binding protein 1a (Mybbp1a).
    Biochem Biophys Res Commun 441: 157-163 (2013).
  6. Tomida J, Oumi A, Okamoto T, Morita Y, Okayama A, Misawa N, Hayashi T, Akaike T, and Kawamura Y.
    Comparative evaluation of agar dilution and broth microdilution methods for antibiotic susceptibility testing of Helicobacter cinaedi.
    Microbiol Immunonol 57: 353-358 (2013).
  7. Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, and Arimoto H.
    Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.
    Mol Cell 52: 794-804 (2013).
 総説
  1. Fujii S and Akaike T.
    Redox signaling by 8-nitro-cyclic guanosine monophosphate: nitric oxide- and reactive oxygen species-derived electrophilic messenger
    Antioxid Redox Signal 19: 1236-1246 (2013).
  2. Akaike T, Nishida M, and Fujii S.
    Regulation of redox signaling by an electrophilic cyclic nucleotide.
    J Biochem 153: 131-138 (2013).
  3. Sawa T, Ihara H, Ida T, Fujii S, Nishida M, and Akaike T.
    Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide.
    Nitric Oxide 34: 10-18 (2013).
  4. 赤池孝章, 藤井重元.
    レドックスシグナル制御と酸化ストレスバイオマーカー.
    精神科救急 16, 69-72 (2013).
  5. 居原秀, 井田智章, 赤池孝章.
    活性酸素シグナルの調節機構?ROS毒性説から脱却した新たな概念.
    Fragrance Journal 41, 75-80 (2013).
  6. 岡本竜哉, 赤池孝章.
    「第0章:インフルエンザの基礎知識」重症新型インフルエンザ診断と治療の手引:鳥インフルエンザウイルスはヒトに感染する.
    メディカル・サイエンス・インターナショナル社 1-18 (2013).
  7. 赤池孝章, 藤井重元.
    「第9章:劇症型ARDSの動物モデル」重症新型インフルエンザ診断と治療の 手引:鳥インフルエンザウイルスはヒトに感染する.
    メディカル・サイエンス・インターナショナル社 147-157 (2013).
  8. 澤 智裕, 居原 秀, 赤池孝章.
    細胞の酸化ストレスを量る. 親電子化合物8-nitro-cGMPの定量を例に.見つける、量る、可視化する!質量分析実験ガイド.
    実験医学別冊 151-158 (2013).
  9. 澤 智裕, 赤池孝章.
    NOシグナリング研究の最前線.
    Heart View 17, 88-92 (2013).
  10. 赤池孝章.
    「フリーラジカル」「一酸化窒素」.
    免疫の辞典 39,109
  11. 澤 智裕, 赤池孝章.
    活性酸素とガス状分子のシグナルネットワーク.
    医学のあゆみ Vol.247,727(2013)

▲年度別メニューへ戻る

2012年

原著論文

  1. Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
    Keap1 degradation by autophagy for the maintenance of redox homeostasis.
    Proc Natl Acad Sci U S A. 109: 13561-13566 (2012).
  2. Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, and Akaike T.
    Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.
    Nature Chem Biol 8: 714-724 (2012).
  3. Oyama K, Khan S, Okamoto T, Fujii S, Ono K, Matsunaga T, Yoshitake J, Sawa T, Tomida J, Kawamura Y, and Akaike T.
    Identification of and screening for human Helicobacter cinaedi infections and carriers via nested PCR.
    J Clin Microbiol 50: 3893-3900 (2012).
  4. Saito Y, Sawa T, Yoshitake J, Ito C, Fujii S, Akaike T, and Arimoto H.
    Nitric oxide promotes recycling of 8-nitro-cGMP, a cytoprotective mediator, into intact cGMP in cells.
    Mol Biosyst 8: 2909-2915 (2012).
  5. Guoguo S, Akaike T, Tao J, Qi C, Nong Z, and Hui L.
    HGF-mediated inhibition of oxidative stress by 8-nitro-cGMP in high glucose-treated rat mesangial cells.
    Free Radic Res 46: 1238-1248 (2012).
  6. Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, and Yamagata K.
    Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
    J Biol Chem 287: 23236-23245 (2012).
  7. Goto T, Ogura Y, Hirakawa H, Tomida J, Morita Y, Akaike T, Hayashi T, and Kawamura Y.
    Complete genome sequence of Helicobacter cinaedi strain PAGU611, isolated in a case of human bacteremia.
    J Bacteriol 194: 3744-3745 (2012).
  8. Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M.
    S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents.
    J Pharm Sci 101: 3222-3229 (2012).
  9. Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, and Akaike T.
    Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis.
    Microbiol Immunol 56: 145-154 (2012).
  10. Ahmed KA, Sawa T, Ihara H, Kasamatsu S, Yoshitake J, Rahaman MM, Okamoto T, Fujii S, and Akaike T.
    Regulation by mitochondrial superoxide and NADPH oxidase of cell formation of nitrated cyclic GMP: potential implications for ROS signaling.
    Biochem J 441: 719-730 (2012).

総説

  1. 澤 智裕,赤池孝章.
    活性酸素のシグナル伝達系と分子標的.
    日本臨床 増刊号. Suppl 8: 273-276 (2012).
  2. 赤池孝章.
    新・活性酸素中毒学.
    ファルマシア. 48: 1 (2012).
  3. 赤池孝章.
    概論:活性酸素によるレドックス恒常性制御の新たなパラダイム転換に迫る.
    実験医学増刊:活性酸素・ガス状分子による恒常性制御と疾患(山本雅之監修, 赤池孝章, 一條秀憲, 森 泰生編集)30(17): 2690-2696 (2012).
  4. 澤 智裕, 赤池孝章.
    ROS・親電子リガンドとガス状分子のシグナルネットワーク.
    実験医学増刊:活性酸素・ガス状分子による恒常性制御と疾患(山本雅之監修, 赤池孝章, 一條秀憲, 森 泰生編集)30(17): 2740-2745 (2012).
  5. 藤井重元, 赤池孝章.
    硫化水素と炎症.
    感染・炎症・免疫. 42(3):235-237 (2012).
  6. 赤池孝章.
    基礎の基礎.
    細胞工学. 特集「活性酸素シグナル制御とレドックスホメオスタシス」監修:赤池孝章. 31(2): 134-137 (2012).
  7. 西田基宏, 澤智裕.
    心不全におけるGタンパク質の酸化修飾と活性酸素・新電子シグナル制御.
    細胞工学. 特集「活性酸素シグナル制御とレドックスホメオスタシス」監修:赤池孝章. 31(2): 150-154 (2012).
  8. 藤井重元, 赤池孝章.
    ニトロ化環状ヌクレオチドによるタンパク質S−グアニル化を介する酸化ストレス適応応答の分子機序
    生化学. 84(2): 124-128 (2012).
  9. 藤井重元, 赤池孝章.
    NOシグナリング NO signaling
    イラストで徹底理解するシグナル伝達キーワード事典(山本 雅,仙波憲太郎,山梨裕司 編).
    羊土社,p.67-69 (2012).
  10. 赤池孝章.
    活性酸素によるレドックス恒常性制御の新たなパラダイム転換に迫る.
    実験医学(増刊):活性酸素・ガス状分子による恒常性制御と疾患(山本雅之監修、赤池孝章、一條秀憲、森 泰生編集)pp. 2690-2696 (2012)

著書

  1. Sawa T, and Akaike T.
    Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment.
    Novel Therapeutic Concepts in Targeting Glioma 247-262 (2012).
  2. Okamoto T, Zaki MH, Fujii S, Sawa T, and Akaike T.
    Nitric oxide-mediated host immune response and microbial pathogenesis.
    Nitric Oxide Synthase Inhibitors: From Animal Studies to Clinical Implications (Tunctan B, editor). 219-233 (2012)

▲年度別メニューへ戻る

2011年

原著論文

  1. Akaike T, van der Vliet A, and Eaton P.
    Frontiers in nitric oxide and redox signaling.
    Nitric Oxide 25: 57-58 (2011).
  2. Ihara H, Ahmed KA, Ida T, Kasamatsu S, Kunieda K, Okamoto T, Sawa T, and Akaike T.
    Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells.
    Nitric Oxide 25: 169-175 (2011).
  3. Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, Shudo K, and Katsuki H.
    Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF.
    J Neurochem 116: 323-333 (2011).
  4. Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Fukuda M, Nako H, Toyama K, Dong YF, Ahmed KA, Sawa T, Akaike T, and Kim-Mitsuyama S.
    Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice.
    Br J Pharmacol 162: 1884-1893 (2011).
  5. Yoshida E, Toyama T, Shinkai Y, Sawa T, Akaike T, Kumagai Y.
    Detoxification of methylmercury by hydrogen sulfide-producing enzyme in mammalian cells.
    Chem Res Toxicol 24: 1633-1635 (2011).
  6. Ishima Y, Yoshida F, Kragh-Hansen U, Watanabe K, Katayama N, Nakajou K, Akaike T, Kai T, Maruyama T, and Otagiri M.
    Cellular uptake mechanisms and responses to NO transferred from mono-and poly-S-nitrosated human serum albumin.
    Free Radic Res 45: 1196-1206 (2011).

総説

  1. Ihara H, Sawa T, Nakabeppu Y, and Akaike T.
    Nucleotides function as endogenous chemical sensors for oxidative stress signaling.
    J Clin Biochem Nutr 48: 33-39 (2011).
  2. Ahmed KA, Sawa T, and Akaike T.
    Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides.
    Amino Acids 41: 123-130 (2011).
  3. Sawa T, Ihara H, and Akaike T.
    Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile.
    Current Topics Med Chem 11: 1854-1860 (2011).
  4. 澤 智裕,小野勝彦,赤池孝章.
    活性酸素・一酸化窒素によるニトロ化シグナルと抗炎症作用.
    感染・炎症・免疫. 41: 12-19 (2011).
  5. 今吉理恵子, 岡本竜哉, 永尾潤一, 長環, 松永勝政, 赤池孝章, 上西秀則.
    植物精油citralのインフルエンザウイルス感染能抑制効果について.
    医学と生物学. 155: 489-494 (2011).
  6. 岡本竜哉, 居原秀, 赤池孝章.
    喫煙と酸化ストレス: Oxidative stress induced by cigarette smoking.
    最新精神医学. 特集号「精神障害者と喫煙」16: 431-439 (2011).
  7. 澤 智裕, 赤池孝章.
    一酸化窒素 nitric oxide/NO.
    免疫の事典(桂 義元, 河本 宏, 小安重夫, 山本一彦 編). 朝倉書店, p. 39 (2011).
  8. 澤 智裕, 赤池孝章.
    活性酸素 reactive oxygen species (ROS).
    免疫の事典(桂 義元, 河本 宏, 小安重夫, 山本一彦 編). 朝倉書店, p. 109 (2011).

▲年度別メニューへ戻る

2010年

原著論文

  1. Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T.
    The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.
    J Biol Chem 285: 23970-23984 (2010).
  2. Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T and Otagiri M.
    One-step preparation of S-nitrosated human serum albumin with high biological activities.
    Nitric Oxide 23: 121-127 (2010).

総説

  1. Okamoto T, Khan S, Oyama K, Fujii S, Sawa T, and Akaike T.
    A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide.
    J Clin Biochem Nutr 46: 14-19 (2010).
  2. Sawa T, Arimoto H, and Akaike T.
    Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles.
    Bioconjugate Chem 21: 1121-1129 (2010).
  3. Akaike T, Fujii S, Sawa T, and Ihara H.
    Cell signaling mediated by nitrated cyclic guanine nucleotide.
    Nitric Oxide 23: 166-174 (2010).
  4. Akaike, T.
    Free radicals abroad.
    SFRBM DOT (Society of Free Radical Biology & Medicine Newsletter) 3: 8 (2010).
  5. 藤井重元, 澤 智裕, 赤池孝章.
    8-Nitro-cGMPの発見と生理機能の解明.
    化学と生物.48: 22-27 (2010).
  6. 澤 智裕, 赤池孝章.
    毒性説から脱した活性酸素研究 —シグナル分子としての活躍—.
    現代化学.469: 34-38 (2010).
  7. 岡本竜哉, 澤 智裕, 赤池孝章.
    Nitric oxide(NO)およびNO関連物質
    日本臨床 増刊号「広範囲血液・尿化学検査, 免疫学的検査-4」.982: 839-842 (2010).
  8. 岡本竜哉, 赤池孝章.
    呼吸器疾患における酸化ストレスと制御シグナルの分子基盤: Molecular mechanisms of nitric oxide- and reactive oxygen species-mediated signalings in the respiratory diseases.
    呼吸.29: 859-866 (2010).
  9. 河村好章, 赤池孝章.
    新興感染症原因菌-Helicobacter cinaedi
    日本医事新報.4514: 59-62 (2010).

▲年度別メニューへ戻る

2009年

原著論文

  1. Zaki MH, Fujii S, Okamoto T, Islam S, Khan S, Ahmed KA, Sawa T, and Akaike T.
    Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis.
    J Immnol 182: 3746-3756 (2009).

総説

  1. 赤池孝章, 岡本竜哉, Zaki MH, 藤井重元, 澤 智裕.
    NO による細胞内感染防御の新しい展開 - New paradigm of host defense against intracellular pathogens by nitric oxide.
    Nihon Hansenbyo Gakkai Zasshi 78: 41-47 (2009).
  2. 岡本竜哉, 澤 智裕, 藤井重元, 赤池孝章.
    活性酸素・NO による感染防御シグナルの新展開 - Antimicrobial signaling mediated by reactive oxygen species and NO.
    細胞. 41: 51-55 (2009).
  3. 赤池孝章.
    活性酸素のシグナル伝達機能—その生理機能の再発見と酸化ストレス研究の新展開
    実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス(谷口直之監修、赤池孝章、鈴木敬一郎、内田浩二編集)pp. 2320-2329 (2009).
  4. 澤 智裕, 有本博一, 赤池孝章.
    チオール基の修飾による活性酸素のセンサー機能制御.
    実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス(谷口直之監修、赤池孝章、鈴木敬一郎、内田浩二編集)pp. 2341-2347 (2009).

▲年度別メニューへ戻る


2008年

原著論文

  1. Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Suenaga A, Maruyama T, Kai T, and Otagiri M.
    S-Nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding.
    J Biol Chem 283: 34966-34975 (2008).
  2. Saito Y, Taguchi H, Fujii S, Sawa T, Kida E, Kabuto C, Akaike T, and Arimoto H.
    8-Nitroguanosines as chemical probes of the protein S-guanylation.
    Chem Commun 5984-5986 (2008).
  3. McCarthy SM, Bove PF, Matthews DE, Akaike T, and van der Vliet A.
    Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch.
    Biochemistry 47: 5832-5840 (2008).
  4. Yoshitake J, Kato K, Yoshioka D, Sueishi Y, Sawa T, Akaike T, and Yoshimura T.
    Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages: Involvement of estrogen receptor-dependent or -independent pathways.
    Nitric Oxide 18: 223-228 (2008).
  5. Urano T, Ito Y, Akao M, Sawa T, Miyata K, Tabata M, Morisada T, Hato T, Yano M, Kadomatsu T, Yasunaga K, Shibata R, Murohara T, Akaike T, Tanihara H, Suda T, and Oike Y.
    Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model.
    Arterioscler Thromb Vasc Biol 28: 827-834 (2008).
  6. Alam MS, Zaki MH, Sawa T, Islam S, Ahmed KA, Fujii S, Okamoto T, and Akaike T.
    Nitric oxide produced in Peyer's patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis.
    Microbiol Immunol 52: 197-208 (2008).
  7. Iwashita H, Fujii S, Kawamura Y, Okamoto T, Sawa T, Masaki T, Nishizono A, Higashi S, Kitamura T, Tamura F, Sasaki Y, and Akaike T.
    Identification of the Major Antigenic Protein of Helicobacter cinaedi and the Immunogenicity During Infections in Humans.
    Clin Vaccine Immunol 15: 513-521 (2008).
  8. Kaneko K, Akuta T, Sawa T, Kim HW, Fujii S, Okamoto T, Nakayama H, Ohigashi H, Murakami A, and Akaike T.
    Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells.
    Cancer Lett 262: 239-247 (2008).

総説

  1. 岡本竜哉, 赤池孝章.
    肺の感染炎症病態におけるニトロ化ストレスとそのバイオマーカー.
    医学のあゆみ. 224: 851-856 (2008).
  2. 澤 智裕, 赤池孝章.
    活性酸素を消去する物質8-ニトロcGMP.
    検査と技術. 36: 678-679 (2008).
  3. 澤 智裕, 赤池孝章.
    一酸化窒素(NO)とシグナル伝達.酸化ストレスの医学.
    診断と治療社(吉川敏一 監修)pp. 138-146 (2008).
  4. 岡本竜哉, 藤井重元, 澤 智裕, 赤池孝章.
    感染病態における NO・活性酸素のシグナル伝達機能:酸化ストレスとその適応応答の分子メカニズム.
    Allergy From the Nose to the Lung. 6: 12-17 (2008).
  5. 岡本竜哉, 赤池孝章.
    教室紹介.
    ウイルス. 58: 229-231 (2008).
  6. 赤池孝章, 澤 智裕.
    放射線・酸化ストレスにおけるNO・活性酸素シグナル制御.
    長崎医学会雑誌(原爆特集号別冊.83: 195-199 (2008).

▲年度別メニューへ戻る


2007年

原著論文

  1. Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, and Akaike T.
    Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
    Nature Chem Biol 3: 727-735 (2007).
  2. Kitamura T, Kawamura Y, Ohkusu K, Masaki T, Iwashita H, Sawa T, Fujii S, Okamoto T, and Akaike T.
    Helicobacter cinaedi cellulitis and bacteremia in immunocompetent hosts after orthopedic surgery.
    J Clin Microbiol 45: 31-38 (2007).
  3. Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Maruyama T, Kai T, and Otagiri M.
    Effect of Endogenous ligands on the biological role of human serum albumin in S-nitrosylation.
    Biochem Biophys Res Commun 364: 790-795 (2007).
  4. Ishima Y, Sawa T, Kragh-Hansen U, Miyamoto Y, Matsushita S, Akaike T, and Otagiri M.
    S-Nitrosylation of human variant albumin Liprizzi (R410C) confers potent antibacterial and cytoprotective properties.
    J Pharmacol Exp Ther 320: 969-977 (2007).

総説

  1. Zaki M H, Okamoto T, Sawa T, Fujii S, and Akaike T.
    Nitrative stress in respiratory inflammation caused by influenza virus infection.
    Clin Exp Allergy Rev 7: 19-26 (2007).
  2. 赤池孝章, 岡本竜哉.
    特発性肺線維症におけるグアニンのニトロ化損傷と発癌との関連 - Guanine nitration in idiopathic pulmonary fibrosis and its implication for carcinogenesis.
    Lung Cancer Update. 46: 1238 (2007).
  3. 岡本竜哉, 赤池孝章.
    iNOSノックアウトマウス.
    分子呼吸器病. 11: 96-103 (2007).
  4. 岡本竜哉, 藤井重元, 澤智裕, 赤池孝章.
    NO による病原体遺伝子変異と感染制御異常:NO-induced mutagenesis for microbial pathogen and host defense suppression.
    日本臨床増刊号新感染症学(上). 65 Suppl 2 Pt. 1: 78-84 (2007).
  5. 岡本竜哉, 澤智裕, 赤池孝章.
    RI の逆襲:意外と使えるアイソトープ:酸化ストレス研究におけるアイソトープの活用.
    細胞工学. 26: 582-588 (2007).
  6. 岡本竜哉, 澤智裕, 赤池孝章.
    35S を用いたタンパク質翻訳後修飾:S-グルタチオン化の評価法.
    細胞工学 別冊 実験プロトコールシリーズ、RI の逆襲. 秀潤社, pp. 99-105 (2007).

▲年度別メニューへ戻る

2006年

原著論文

  1. Unno Y, Akuta T, Sakamoto Y, Horiuchi S, and Akaike T.
    Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes.
    Nitric Oxide 15: 125-132 (2006).
  2. Terasaki Y, Akuta T, Terasaki M, Sawa T, Mori T, Okamoto T, Ozaki M, Takeya M, and Akaike T.
    Guanine nitration in idiopathic pulmonary fibrosis and its implication for carcinogenesis.
    Am J Respir Crit Care Med 174: 665-673 (2006).
  3. Sawa T, Tatemichi M, Akaike T, Barbin A, and Ohshima H.
    Analysis of urinary 8-nitroguanine, a marker of nitrative nucleic acid damage, by high-performance liquid chromatography-electrochemical detection coupled with immunoaffinity purification: association with cigarette smoking.
    Free Radic Biol Med 40: 711-720 (2006).
  4. Sakai K, Suzuki H, Oda H, Akaike T, Azuma Y, Murakami T, Sugi K, Ito T, Ichinose H, Koyasu S, and Shirai M.
    Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase.
    J Biol Chem 281: 17736-17742 (2006).
  5. Ohshima H, Sawa T, and Akaike T.
    8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis.
    Antioxid Redox Signal 8: 1033-1045 (2006).
  6. Alam MS, Zaki MH, Yoshitake J, Akuta T, Ezaki T, and Akaike T.
    Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection.
    Microb Pathog 40: 116-125 (2006).

総説

  1. Akuta T, Zaki MH, Yoshitake J, Okamoto T, and Akaike T.
    Nitrative stress through formation of 8-nitroguanosine: insights into microbial pathogenesis.
    Nitric Oxide 14: 101-108 (2006).
  2. 澤智裕, 岡本竜哉, 赤池孝章.
    NO ガスが病原菌をやっつける:NO による生体分子のニトロ化およびニトロソ化を介するユニークな抗菌作用.
    現代化学. 424: 51-56 (2006).
  3. 澤智裕, 芥照夫, 有本博一, 赤池孝章.
    ニトロ化修飾反応による NO の新しいシグナル機構.
    細胞工学. 25: 132-136 (2006).
  4. 田村文雄, 赤池孝章.
    nitric oxide と酸化ラジカル.
    敗血症の解明と治療戦略. 医薬ジャーナル社(東京)pp 117-124 (2006).
  5. 田村文雄, 澤智裕, 赤池孝章.
    敗血症とショックの病態.
    化学療法の領域. 22: 19-24 (2006).
  6. 赤池孝章.
    バイオスピンのケミカルバイオロジーとシグナル伝達.
    細胞工学. 25: 126-127 (2006).
  7. 岡本竜哉, 赤池孝章.
    一酸化窒素(NO)による新しい感染防御機構.
    医学のあゆみ. 酸化ストレスーフリーラジカル医学生物学の最前線ー Ver. 2: 219-223 (2006).

▲年度別メニューへ戻る

2005年ー2001年

原著論文
Scopus による被引用回数 50 回以上の英文論文のみを掲載
(全 38報の英文論文中 19 報が該当; 2015年 8 月 17 日現在)

  1. Zaki, M.H., Akuta, T., Akaike, T.
    Nitric oxide-induced nitrative stress involved in microbial pathogenesis.
    Journal of Pharmacological Sciences 98: 117-129 (2005).
  2. Okamoto T, Gohil K, Finkelstein EI, Bove P, Akaike T, and van der Vliet A.
    Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice.
    Am J Physiol Lung Cell Mol Physiol 286: L198-L209 (2004).
  3. Greish K, Sawa T, Fang J, Akaike T, and Maeda H.
    SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours.
    J Control Release 97: 219-230 (2004).
  4. Fang J, Sawa T, Akaike T, Greish K, and Maeda H.
    Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
    Int J Cancer 109: 1-8 (2004).
  5. Kuwahara, H., Kanazawa, A., Wakamatu, D., Morimura, S., Kida, K., Akaike, T., and Maeda, H.
    Antioxidative and antimutagenic activities of 4-vinyl-2, 6-dimethoxyphenol (canolol) isolated from canola oil.
    J Agric Food Chem 52: 4380-4387 (2004).
  6. Okamoto, T., Akuta, T., Tamura, F., van der Vliet, A., Akaike, T.
    Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation
    Biol Chem. 385: 997-1006 (2004).
  7. Fang J, Sawa T, Akaike T, Greish K, Maeda H..
    Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
    Int J Cancer. 109: 1-8 (2004).
  8. Morikawa K, Shimokawa H, Matoba T, Kubota H, Akaike T, Talukder MA, Hatanaka M, Fujiki T, Maeda H, Takahashi S, and Takeshita A.
    Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization.
    J Clin Invest 112: 1871-1879 (2003).
  9. Matoba T, Shimokawa H, Morikawa K, Kubota H, Kunihiro I, Urakami-Harasawa L, Mukai Y, Hirakawa Y, Akaike T, and Takeshita A.
    Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels.
    Arterioscler Thromb Vasc Biol 23: 1224-1230 (2003).
  10. Fang J, Sawa T, Akaike T, Akuta T, Sahoo SK, Khaled G, Hamada A, and Maeda H.
    In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.
    Cancer Res 63: 3567-3574 (2003).
  11. Akaike T, Okamoto S, Sawa T, Yoshitake J, Tamura F, Ichimori K, Miyazaki K, Sasamoto K, and Maeda H.
    8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis.
    Proc Natl Acad Sci USA 100: 685-690 (2003).
  12. Tanaka S, Akaike T, Fang J, Beppu T, Ogawa M, Tamura F, Miyamoto Y, Maeda H..
    Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour.
    Br J Cancer. 88: 902-909 (2003).
  13. Wu J, Akaike T, Hayashida K, Miyamoto Y, Nakagawa T, Miyakawa K, Muller-Esterl W, and Maeda H.
    Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues.
    Int J Cancer 98: 29-35 (2002).
  14. Sahoo SK, Sawa T, Fang J, Tanaka S, Miyamoto Y, Akaike T, and Maeda H.
    Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity.
    Bioconjug Chem 13: 1031-1038 (2002).
  15. Fang J, Sawa T, Akaike T, and Maeda H.
    Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide.
    Cancer Res 62: 3138-3143 (2002).
  16. Alam MS, Akaike T, Okamoto S, Kubota T, Yoshitake J, Sawa T, Miyamoto Y, Tamura F, and Maeda H.
    Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities.
    Infect Immun 70: 3130-3142 (2002).
  17. Wu J, Akaike T, Hayashida K, Okamoto T, Okuyama A, and Maeda H.
    Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.
    Jpn J Cancer Res 92: 439-451 (2001).
  18. Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, and Maeda H.
    Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation.
    J Biol Chem 276: 29596-29602 (2001).
  19. Akaike T.
    Role of free radicals in viral pathogenesis and mutation
    Reviews in Medical Virology 11: 87-101 (2001).

総説

  1. Zaki MH, Akuta T, and Akaike T.
    Nitric oxide-induced nitrative stress involved in microbial pathogenesis..
    J Pharmacol Sci 98: 117-129 (2005).
  2. 赤池孝章.
    NOによる8-ニトログアノシンの生体内生成と生物効果.
    酸化ストレスマーカー. 学会出版センター(東京)pp 120-124 (2005).
  3. 岡本竜哉, 赤池孝章.
    肺の炎症病態における NO・活性酸化窒素種の生成とマトリックス・メタロプロテアーゼの活性発現調節.
    医学のあゆみ. 214: 919-925 (2005).
  4. 芥照夫, 赤池孝章.
    Nitric oxide (NO) および NO 関連物質.
    日本臨床. 63 Suppl 8: 791-793 (2005).
  5. 芥照夫, 赤池孝章.
    プリン異化代謝と活性酸素・NO: 尿酸の抗酸化作用とニトログアニンのシグナル機能.
    Gout and Nucleic Acid Metabolism. 29: 157 (2005).
  6. 芥照夫, 赤池孝章.
    一酸化窒素(NO)の新しいシグナル伝達機構 - グアノシンのニトロ化を介するNOシグナル.
    化学と生物. 43: 420-422 (2005).
  7. 芥照夫, 赤池孝章.
    注目される酸化ストレスマーカー: NOマーカー.
    臨床検査. 49: 139-143 (2005).
  8. 芥照夫, 赤池孝章.
    レドックスーストレス防御の医学.
    医学のあゆみ 別冊 NO biology. 56-60 (2005).
  9. Fang J, Akaike T, and Maeda H.
    Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment.
    Apoptosis 9: 27-35 (2004).
  10. Okamoto, T., Akuta, T., Tamura, F., van der Vliet, A., and Akaike, T.
    Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation
    Biol Chem 385: 997-1006 (2004).

著書

  1. Kanazawa A, Sawa T, Akaike T, and Maed, H. 
    Generation of lipid peroxyl radicals from oxidized edible oils and heme-iron: Suppression of DNA damage by unrefined oils and vegetable extracts.
    Free Radicals in Food. Chemistry, Nutrition, and Health Effects, ACS Symposium Series 807: 282-300 (2002).
  2. Ishizuka K, Kimura T, Yoshitake J, Akaike T, Shono M, Takamatsu J, Katsuragi S, Kitamura, T, and Miyakawa T.
    Possible assessment for antioxidant capacity in Alzheimer's disease by measuring lymphocyte heme oxygenase-1 expression with real-time RT-PCR.
    Alzheimer's Disease: Vascular Etiology and Pathology, Annals of The New York Academy of Sciences 977: 173-178 (2002).

▲年度別メニューへ戻る

2000年ー1996年

原著論文
Scopus による被引用回数 50 回以上の英文論文のみを掲載
(全 63 報の英文論文中 30 報が該当; 2015年 8 月 17 日現在)

  1. Yogo K, Shimokawa H, Funakoshi H, Kandabashi T, Miyata K, Okamoto S, Egashira K, Huang P, Akaike T, and Takeshita A.
    Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice.
    Arterioscler Thromb Vasc Biol 20: E96-E100 (2000).
  2. Suga M, Iyonaga K, Okamoto T, Gushima Y, Miyakawa H, Akaike T, and Ando M.
    Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias.
    Am J Respir Crit Care Med 162: 1949-1956 (2000).
  3. Sawa T, Akaike T, and Maeda H.
    Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase.
    J Biol Chem 275: 32467-32474 (2000).
  4. Akaike T, Fujii S, Kato A, Yoshitake J, Miyamoto Y, Sawa T, Okamoto S, Suga M, Asakawa M, Nagai Y, and Maeda H.
    Viral mutation accelerated by nitric oxide production during infection in vivo.
    FASEB J 14: 1447-1454 (2000).
  5. Sawa T, Wu J, Akaike T, and Maeda H.
    Tumor-targeting chemotherapy by a xanthine oxidase-polymer conjugate that generates oxygen radicals in tumor tissue.
    Cancer Res 60: 666-671 (2000).
  6. Kuwahara H, Miyamoto Y, Akaike T, Kubota T, Sawa T, Okamoto S, and Maeda H.
    Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production.
    Infect Immun 68: 4378-4383 (2000).
  7. Akaike T, Maeda H.
    Nitric oxide and virus infection.
    Immunology. 101: 300-308 (2000).
  8. Sawa T, Nakao M, Akaike T, Ono K, and Maeda H.
    Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables.
    J Agric Food Chem 47: 397-402 (1999).
  9. Inoue K, Akaike T, Miyamoto Y, Okamoto T, Sawa T, Otagiri M, Suzuki S, Yoshimura T, and Maeda H.
    Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo.
    J Biol Chem 274: 27069-27075 (1999).
  10. Fujii S, Akaike T, and Maeda H.
    Role of nitric oxide in pathogenesis of herpes simplex virus encephalitis in rats.
    Virology 256: 203-212 (1999).
  11. Doi K, Akaike T, Fujii S, Tanaka S, Ikebe N, Beppu T, Shibahara S, Ogawa M, and Maeda H.
    Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth.
    Br J Cancer 80: 1945-1954 (1999).
  12. Maeda, H., Wu, J., Okamoto, T., Maruo, K., Akaike, T.
    Kallikrein-kinin in infection and cancer
    Immunopharmacology 43: 115-128 (1999).
  13. Wu J, Akaike T, and Maeda H.
    Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger.
    Cancer Res 58: 159-165 (1998).
  14. Sawa T, Akaike T, Kida K, Fukushima Y, Takagi K, and Maeda H.
    Lipid peroxyl radicals from oxidized oils and heme-iron: implication of a high-fat diet in colon carcinogenesis.
    Cancer Epidemiol Biomarkers Prev 7: 1007-1012 (1998).
  15. Noguchi Y, Wu J, Duncan R, Strohalm J, Ulbrich K, Akaike T, and Maeda H.
    Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues.
    Jpn J Cancer Res 89: 307-314 (1998).
  16. Akaike T, Suga M, and Maeda H.
    Free radicals in viral pathogenesis: molecular mechanisms involving superoxide and NO.
    Proc Soc Exp Biol Med 217: 64-73 (1998).
  17. Maeda, H., Akaike, T.
    Nitric oxide and oxygen radicals in infection, inflammation and cancer.
    Biochemistry (Mosc). 63: 854-865 (1998).
  18. Sato, K., Suga, M., Akaike, T., Fujii, S., Muranaka, H., Doi, T., Maeda, H., Ando, M.
    Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice.
    Am J Respir Crit Care Med. 157: 853-857 (1998).
  19. Maeda, H., Okamoto, T., Akaike, T.
    Human matrix metalloprotease activation by insults of bacterial infection involving
    proteases and free radicals

    Biological Chemistry379: 193-200 (1998).
  20. Umezawa K, Akaike T, Fujii S, Suga M, Setoguchi K, Ozawa A, and Maeda H.
    Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice.
    Infect Immun 65: 2932-2940 (1997).
  21. Okamoto T, Akaike T, Suga M, Tanase S, Horie H, Miyajima S, Ando M, Ichinose Y, and Maeda H.
    Activation of human matrix metalloproteinases by various bacterial proteinases.
    J Biol Chem 272: 6059-6066 (1997).
  22. Okamoto T, Akaike T, Nagano T, Miyajima S, Suga M, Ando M, Ichimori K, and Maeda H.
    Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: a novel mechanism for procollagenase activation involving nitric oxide.
    Arch Biochem Biophys 342: 261-274 (1997).
  23. Hooper DC, Bagasra O, Marini JC, Zborek A, Ohnishi ST, Kean R, Champion JM, Sarker AB, Bobroski L, Farber JL, Akaike T, Maeda H, and Koprowski H.
    Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.
    Proc Natl Acad Sci USA 94: 2528-2533 (1997).
  24. Akaike T, Inoue K, Okamoto T, Nishino H, Otagiri M, Fujii S, and Maeda H.
    Nanomolar quantification and identification of various nitrosothiols by high performance liquid chromatography coupled with flow reactors of metals and Griess reagent.
    J Biochem (Tokyo) 122: 459-466 (1997).
  25. Maruo K, Akaike T, Ono T, Okamoto T, and Maeda H.
    Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease.
    J Allergy Clin Immunol 100: 253-260 (1997).
  26. Setoguchi K, Takeya M, Akaike T, Suga M, Hattori R, Maeda H, Ando M, and Takahashi K.
    Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats.
    Am J Pathol 149: 2005-2022 (1996).
  27. Doi K, Akaike T, Horie H, Noguchi Y, Fujii S, Beppu T, Ogawa M, and Maeda H.
    Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth.
    Cancer 77: 1598-1604 (1996).
  28. Akaike T, and Maeda H.
    Quantitation of nitric oxide using 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO).
    Methods Enzymol 268: 211-221 (1996).
  29. Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, and Maeda H.
    Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.
    Proc Natl Acad Sci USA 93: 2448-2453 (1996).
  30. Miyamoto Y, Akaike T, Yoshida M, Goto S, Horie H, and Maeda H.
    Potentiation of nitric oxide-mediated vasorelaxation by xanthine oxidase inhibitors.
    Proc Soc Exp Biol Med 211: 366-373 (1996).

総説

  1. Akaike T.
    Mechanisms of biological S-nitrosation and its measurement.
    Free Rad Res 33: 461-469 (2000).
  2. Akaike T, and Maeda H.
    Nitric oxide and virus infection.
    Immunology 101: 300-308 (2000).
  3. Miyamoto Y, Akaike T, and Maeda H.
    S-nitrosylated human alpha(1)-protease inhibitor.
    Biochim Biophys Acta 1477: 90-97 (2000).
  4. Maeda, H., Wu, J., Okamoto, T., Maruo, K., and Akaike, T.
    Kallikrein-kinin in infection and cancer.
    Immunopharmacology 43: 115-128 (1999).
  5. Akaike T, Suga M, and Maeda H.
    Free radicals in viral pathogenesis: molecular mechanisms involving superoxide and NO.
    Proc Soc Exp Biol Med 217: 64-73 (1998).
  6. Maeda H, Okamoto T, and Akaike T.
    Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals.
    Biol Chem 379: 193-200 (1998).
  7. Maeda H, and Akaike T.
    Nitric oxide and oxygen radicals in infection, inflammation, and cancer.
    Biochemistry (Mosc) 63: 854-865 (1998).
  8. Maeda, H., Akaike, T., Wu, J., Noguchi , Y.and Sakata, Y.
    Bradykinin and nitric oxide in infectious disease and cancer.
    Immunopharmacology 33: 222-230 (1996).

著書

  1. Akaike T, and Inoue K.
    S-Nitrosothiol detection by HPLC coupled with flow reactors of Hg2+ and Griess reagent.
    Experimental Protocols for Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) 20-24 (2000).
  2. Miyamoto Y, Akaike T, and Maeda H.
    Bioassay for antioxidant activity: Determination of scavenging capacity of antioxidants against lipid peroxyl radicals.
    Experimental Protocols for Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) 45-49 (2000).
  3. Akaike T, Miyamoto Y, and Sawa T.
    Xanthine oxidase.
    Experimental Protocols for Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) 36-141 (2000).
  4. Akaike T, and Miyamoto Y.
    Scavenging NO in experimental animals.
    Experimental Protocols for Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) 306-310 (2000).
  5. Akaike T, and Maeda H.
    Pathophysiological effects of high-output production of nitric oxide.
    Nitric Oxide 733-745 (2000).
  6. Maeda H, Wu J, Okuyama A, and Akaike T.
    Vascular permeability enhancement by peroxynitrite involving activation of collagenase followed by subsequent protease cascade leading to bradykinin generation in tumor.
    The Biology of Nitric Oxide Part 7: 204 (2000).
  7. Akaike T, and Maeda H.
    Viral mutation and evolution accelerated by nitric oxide-induced oxidative stress.
    The Biology of Nitric Oxide Part 7: 16 (2000).
  8. Miyamoto Y, Akaike T, Kuwahara H, Kubota T, Yoshimatsu S, Sawa T, Okamoto S, and Maeda H.
    Urease functions as a defense system of Helicobacter pylori against peroxynitrite through the production of carbon dioxide.
    The Biology of Nitric Oxide Part 7: 30 (2000).
  9. Sawa T, Akaike T, and Maeda H.
    Tyrosine nitration by peroxynitrite generated from xanthine oxidase-hypoxanthine and nitric oxide.
    The Biology of Nitric Oxide Part 7: 174 (2000).
  10. Ikebe N, Akaike T, Miyamoto Y, Ogawa M, and Maeda H.
    Protective effect of S-nitroso-a1-protease inhibitor on hepatic ischemia-reperfusion injury.
    The Biology of Nitric Oxide Part 7: 51 (2000).
  11. Akaike T, and Maeda H.
    Nitric oxide in influenza.
    Nitric Oxide and Infection 397-415 (1999).
  12. Akaike T.
    Nitric oxide in infectious diseases.
    Guanidino Cmpounds 175-179 (1999).
  13. Maeda H, and Akaike T.
    Infection, inflammation, and cancer mediated by oxygen radicals and nitric oxide.
    Nitric Oxide in Transplant Rejection and Anti-Tumor Defense 277-294 (1998).
  14. Akaike T, Inoue K, Okamoto T, Miyamoto Y, and Maeda H.
    Specific and sensitive quantitation of various nitrosothiols by high performance liquid chromatography coupled with flow reactor systems.
    The Biology of Nitric Oxide Part 6:45-46 (1998).
  15. Okamoto T, Akaike T, Suga M, Maeda H, and Ando M.
    Redox-based remodeling of extracellular matrix by matrix metalloproteinases involving peroxynitrite and glutathione.
    The Biology of Nitric Oxide Part 6:283 (1998).
  16. Doi K, Akaike T, Fujii S, Ikebe N, Beppu T, Ogawa M, Shibahara S, and Maeda H.
    Induction of heme oxygenase and nitric oxide synthase in an experimental solid tumor in rats.
    The Biology of Nitric Oxide Part 6:187 (1998).
  17. Tayama S, Akaike T, Tsunoda R, Li CG, Yoshida M, Yasue H, and Maeda H.
    Characterization of EDRF response by using liposome PTIO in vitro and in vivo: Implication of nitrosothiol formation to EDRF response.
    The Biology of Nitric Oxide Part 6:311 (1998).
  18. Akizuki E, Akaike T, Yamaguchi Y, Miyamoto Y, Maeda H, and Ogawa M.
    Role of NO and superoxide in injury of cardiac allografts transplanted in rats.
    The Biology of Nitric Oxide Part 6: 213 (1998).
  19. Fujii S, Akaike T, and Maeda H.
    Role of nitric oxide in the pathogenesis of herpes simplex virus encephalitis in rats.
    The Biology of Nitric Oxide Part 6:18 (1998).
  20. Li CG, Rand MJ, Akaike T, Yoshida M, and Maeda H.
    Activation of nitrergic mechanism by black widow spider venom and a-latrotoxin.
    The Biology of Nitric Oxide Part 6: 80 (1998).
  21. Maeda H, and Akaike T.
    Bacterial proteases as pathogenic factors in view of septicemia and shock.
    Protease Inhibitors: Novel Therapeutic Application and Development 2.1.1-2.1.33 (1997).
  22. Maeda H, Okamoto T, Akaike T, Miyajima S, Suga M, Ando M, and Ichinose Y.
    Activation of matrix metalloproteinases by bacterial proteinases and pathogenic implication.
    Medical Aspects of Proteases and Protease Inhibitors 128-138 (1997).
  23. Maeda H, Shin Y-H, Akaike T, and Yoshida M.
    Septic shock: Prevention by NO-scavenger (PTIO) and kinin inhibitor.
    Shock 43-52 (1996).
  24. Akaike T, Sato K, and Maeda H.
    Activation of neocarzinostatin by NADPH/cytochrome P-450 reductase: Proposal of an ultimate mode of action in cells involving oxygen free radicals.
    Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug 155-166 (1996).
  25. Shin Y-H, Akaike T, and Maeda H.
    Therapeutic effects of the soybean trypsin inhibitor and its gelatin conjugate on the pseudomonal elastase induced shock in guinea pig.
    Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems 339-340 (1996).
  26. Akaike T, and Maeda H.
    Pathogenesis of influenza virus-induced pneumonia: Involvement of both nitric oxide and superoxide anion.
    The Biology of Nitric Oxide Part 5:25 (1996).
  27. Akaike T, and Maeda H.
    Direct quantitation of nitric oxide released from cells using liposome-encapsulated PTIO.
    The Biology of Nitric Oxide Part 5:171 (1996).
  28. Doi K, Akaike T, Noguchi Y, Horie H, Ogawa M, and Maeda H.
    Induction of nitric oxide biosynthesis and its role in solid tumor.
    The Biology of Nitric Oxide Part 5:163 (1996).

▲年度別メニューへ戻る

1995年以前

原著論文
Scopus による被引用回数 50 回以上の英文論文のみを掲載
(全 38報の英文論文中 14 報が該当; 2015年 8 月 17 日現在)

  1. Akaike T, Weihe E, Schaefer M, Fu ZF, Zheng YM, Vogel W, Schmidt H, Koprowski H, and Dietzschold B.
    Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain.
    J Neurovirol 1: 118-125 (1995).
  2. Aoki, H., Akaike, T., Abe, K., Kuroda, M., Arai, S., Okamura, R., Negi, A., Maeda, H.
    Antiviral effect of oryzacystatin, a proteinase inhibitor in rice, against herpes simplex virus type 1 in vitro and in vivo.
    Antimicrob Agents Chemother. 39: 846-849 (1995).
  3. Yoshida M, Akaike T, Wada Y, Sato K, Ikeda K, Ueda S, and Maeda H.
    Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity.
    Biochem Biophys Res Commun 202: 923-930 (1994).
  4. Maeda H, Noguchi Y, Sato K, and Akaike T.
    Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor.
    Jpn J Cancer Res 85: 331-334 (1994).
  5. Maeda, H., Akaike, T., Yoshida, M.,
    Multiple functions of nitric oxide in pathophysiology and microbiology: Analysis by a new nitric oxide scavenger.
    J Leukoc Biol. 56: 588-592 (1994).
  6. Doi T, Ando M, Akaike T, Suga M, Sato K, and Maeda H.
    Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis.
    Infect Immun 61: 1980-1989 (1993).
  7. Akaike T, Yoshida M, Miyamoto Y, Sato K, Kohno M, Sasamoto K, Miyazaki K, Ueda S, and Maeda H.
    Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.
    Biochemistry 32: 827-832 (1993).
  8. Sato K, Akaike T, Kohno M, Ando M, and Maeda H.
    Hydroxyl radical production by H2O2plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme.
    J Biol Chem 267: 25371-25377 (1992).
  9. Akaike T, Sato K, Ijiri S, Miyamoto Y, Kohno M, Ando M, and Maeda H.
    Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides.
    Arch Biochem Biophys 294: 55-63 (1992).
  10. Oda T, Akaike T, Sato K, Ishimatsu A, Takeshita S, Muramatsu T, and Maeda H.
    Hydroxyl radical generation by red tide algae.
    Arch Biochem Biophys 294: 38-43 (1992).
  11. Maeda H, and Akaike T.
    Oxygen free radicals as pathogenic molecules in viral diseases.
    Proc Soc Exp Biol Med 198: 721-727 (1991).
  12. Akaike T, Ando M, Oda T, Doi T, Ijiri S, Araki S, and Maeda H.
    Dependence on O2¯generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.
    J Clin Invest 85: 739-745 (1990).
  13. Oda T, Akaike T, Hamamoto T, Suzuki F, Hirano T, and Maeda H.
    Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD.
    Science 244: 974-976 (1989).
  14. Molla A, Yamamoto T, Akaike T, Miyoshi S, and Maeda H.
    Activation of hageman factor and prekallikrein and generation of kinin by various microbial proteinases.
    J Biol Chem 264: 10589-10594 (1989).

総説

  1. Maeda H, Akaike T, Yoshida M, and Suga M.
    Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger.
    J Leukoc Biol 56: 588-592 (1994).
  2. Maeda H, and Akaike T.
    Oxygen free radicals as pathogenic molecules in viral diseases.
    Proc Soc Exp Biol Med 198: 721-727 (1991).
 著書
  1. Maeda H, Sato K, and Akaike T.
    Superoxide radical generation from heterocyclic amines.
    the Proceedings of the Twenty-Third International Symposium of the Princess Takamatsu Cancer Research Fund 103-112 (1995).
  2. Maeda H, Sato K, and Akaike T.
    Inactivation and fragmentation of a1-protease inhibitor by Cu,Zn-superoxide dismutase and hydrogen peroxide via liberation of hydroxyl radical.
    Biological Functions of Proteinases and Inhibitors 253-270 (1994).
  3. Akaike T, and Maeda H.
    Molecular pathogenesis of influenza virus pneumonia: Impacts of proteases, kinins and oxygen radicals derived from hosts.
    Basic and Clinical Aspects of Pulmonary Fibrosis 213-227 (1994).
  4. Maeda H, Akaike T, Yoshida M, and Noguchi Y.
    A new nitric oxide scavenger, imidazolineoxyl N-oxide derivative and its effects in pathophysiology and microbiology.
    Current Topics in Microbiology and Immunology 37-50 (1994).
  5. Akaike T, Yoshida M, Sato K, Ueda S, and Maeda H.
    Therapeutic potential of imidazolineoxyl N-oxide against endotoxin shock rat.
    The Biology of Nitric Oxide Part 3, Physiological and Clinical Aspects 280-283 (1994).
  6. Maeda H, Akaike T, Sakata Y, and Maruo K.
    Role of bradykinin in microbial infection: Enhancement of septicemia by microbial proteases and kinin.
    Agents and Actions, Supplements 42: 159-165 (1993).
  7. Maeda H, Maruo K, Akaike T, Kaminishi H, and Hagiwara Y.
    Microbial proteinases as a universal trigger of kinin generation in microbial infections.
    Agents and Actions Supplements 38: 362-369 (1992).
  8. Kojima Y, Akaike T, and Maeda H.
    Free radical scavenging potential of the lung in influenza virus-infected mice.
    Oxygen Radicals 461-464 (1992).
  9. Maeda H, Akaike T, and Maruo K.
    Pathogenic role of microbial proteases at cellular and molecular levels.
    Frontiers of Mucosal Immunology 1: 553-558 (1991).
  10. Akaike T, Sato K, Kohno M, and Maeda H.
    PQQ as a generator and scavenger of oxygen radicals.
    Enzymes Dependent on Pyridoxal Phosphate and Other Carbonyl Compounds as Cofactors 511-513 (1991).
  11. Oda T, Akaike T, Hirano T, and Maeda H.
    Therapeutic effect of pyran-copolymer-conjugated SOD on the mouse influenza virus infection.
    Medical, Biochemical and Chemical Aspects of Free Radicals 747-750 (1988).

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